Against Antimicrobial Resistance

Antimicrobial Drugs in Fighting against Antimicrobial Resistance

The outbreak of antimicrobial resistance, together with the lack of newly developed antimicrobial drugs, represents an alarming signal for both human and animal healthcare worldwide. Selection of rational dosage regimens for traditional antimicrobial drugs based on pharmacokinetic/pharmacodynamic principles as well as development of novel antimicrobials targeting new bacterial targets or resist...

Antimicrobial resistance among and therapeutic options against gram-negative pathogens.

Gram-negative bacterial pathogens are a common cause of infection, and the prevalence and rates of resistance among these pathogens to existing antimicrobial agents are increasing. beta-Lactamase-mediated resistance is of particular concern. High-level resistance attributable to beta-lactamase expression alone or in combination with other mechanisms is becoming increasingly prevalent among Ente...

Legionnaires ’ disease • The European community strategy against antimicrobial resistance

" Neither the European Commission nor any person acting on behalf of the Commission is responsible for the use which might be made of the following information " Leg i on n ai res ' di sease • The European community strategy against antimicrobial resistance • Legionnaires' disease clusters associated Peer-reviewed European information on communicable disease surveillance and control O u t b r e...

No Room for Complacency: The Fight Against Antimicrobial Resistance

Lipid A Acylation and Bacterial Resistance against Vertebrate Antimicrobial Peptides

The Salmonellae PhoP-PhoQ virulence regulators induce resistance to host cationic antimicrobial peptides (CAMP) after infection of vertebrate tissues, and Mg2+ or Ca2+ limitation. The PhoP-PhoQ activated gene, pagP, was identified as important to inducible CAMP resistance and increased acylation of lipid A, the major component of the outer leaflet of the outer membrane. pagP mutants demonstrate...